Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Mathematical Modelling to Guide Drug Development for Malaria Elimination
Mathematical models of the dynamics of a drug within the host are now frequently used to guide drug development These generally focus on assessing the efficacy and duration of response to guide patient therapy Increasingly antimalarial drugs are used at the population level to clear infections provide chemoprevention and to reduce onward transmissi...
In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System
Abstract The release rate of doxorubicin DOX from the drugdelivery system DDS DC Bead was studied by miniaturized in vitro methods freeflowing and sample reservoir The dependencies of the release mechanisms on in vitro system conditions were investigated experimentally and by theoretical modeling An inverse relationship was found between release...
Orally Disintegrating Films: A Modern Expansion In Drug Delivery System
Abstract Over the past few decades tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy safety and patient acceptability As discovery and development of new chemical agents is a complex expensive and time consuming process so recent trends are shifting toward designing and developing innovative drug de...
Insights into CYP2B6-mediated drug–drug interactions
Abstract Mounting evidence demonstrates that CYPB plays a much larger role in human drug metabolism than was previously believed The discovery of multiple important substrates of CYPB as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the enzyme Th...
Reprint Of “Mixed-Mode Chromatography In Pharmaceutical And Biopharmaceutical Applications”
Abstract Mixedmode chromatography MMC is a fast growing area in recent years thanks to the new generation of mixedmode stationary phases and better understanding of multimode interactions MMC has superior applications in the separation of compounds that are not retained or not well resolved by typical reversedphase LC methods especially for polar...
Patient Perceptions Concerning Clinical Trials In Oncology Patients
Abstract Background Clinical trials are critical to scientifically evaluate promising new therapies in oncology but patient accrual to these studies is persistently low Patient preference plays an important role in enrollment in these trials We performed this survey to evaluate the perceptions of newly di
Distribution Of Bacterial Contamination In Non-sterile Pharmaceutical Materials And Assessment Of Its Risk To The Health Of The Final Consumers Quantitatively
Abstract Bacterial contamination control in pharmaceutical products is a critical aspect in the field of drug manufacturing industry due to the encountered risk to the patients health and possibly their life The application of commercial bacterial identification system is crucial to identify the type of contamination and its source to anticipate t...
Zika Virus Replicons For Drug Discovery
Abstract The current epidemic of Zika virus ZIKV has underscored the urgency to establish experimental systems for studying viral replication and pathogenesis and countermeasure development Here we report two ZIKV replicon systems a luciferase replicon that can differentiate between viral translation and RNA synthesis and a stable luciferase repli...
The Promises Of Quantitative Systems Pharmacology Modelling For Drug Development
Abstract Recent growth in annual new therapeutic entity NTE approvals by the US Food and Drug Administration FDA suggests a positive trend in current research and development RD output Prior to this the cost of each NTE was considered to be rising exponentially with compound failure occurring mainly in clinical phases Quantitative Systems Pharma
Temporal Trends And Factors Associated With Cardiovascular Drug Development, 1990 To 2012
Summary Cardiovascular disease remains a leading cause of death but stakeholders have recently raised concerns about the pace of innovation and investment in developing new therapeutics Here the authors characterized temporal trends in cardiovascular research and development over the past decades and the likelihood of successful completion of pre...
