Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Validated Spectrometric Determination Of Penciclovir And Entecavir In Bulk And In Pharmaceutical Preparations
Abstract Simple rapid and sensitive spectroscopic methods were developed and validated for the determination of antiviral agents namely penciclovir PCV and entecavir ETV The first method is based on measuring the native fluorescence of each of the cited drugs at its optimum excitation and emission wavelengths The fluorescence intensity was measure...
Validation Of A Liquid Chromatographic Method For The Pharmaceutical Quality Control Of Products Containing Elacridar
Abstract Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as Pglycoprotein and Breast Cancer Resistance Protein Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of m...
Challenges Of Glycosylation Analysis And Control: An Integrated Approach To Producing Optimal And Consistent Therapeutic Drugs
Abstract Glycosylation of therapeutic proteins has a profound impact on their safety and efficacy Many factors shape the glycosylation of biotherapeutics ranging from expression systems and cell culture processes to downstream purification strategies Various analytical technologies have been developed to address questions concerning different aspe...
Translational Medicine Guide Transforms Drug Development Processes: The Recent Merck Experience
Abstract Merck is implementing a questionbased Translational Medicine Guide TxM Guide beginning as early as lead optimization into its stagegate drug development process Initial experiences with the TxM Guide which is embedded into an integrated development plan tailored to each development program demonstrated opportunities to improve target unde...
Assessing The Potential Of Mathematical Modelling In Designing Drug-releasing Orthopaedic Implants
Abstract Orthopaedic implants have been the subject of intense research in recent years with academics clinicians and industrialists seeking to broaden our understanding of their function and potential consequences within the human body Current research is focussed on ways to improve the integration of an orthopaedic device within the body whether...
Evaluation Of Giardia Lamblia Thioredoxin Reductase As Drug Activating Enzyme And As Drug Target
Abstract The antioxidative enzyme thioredoxin reductase TrxR has been suggested to be a drug target in several pathogens including the protist parasite Giardia lamblia TrxR is also believed to catalyse the reduction of nitro drugs eg metronidazole and furazolidone a reaction required to render these compounds toxic to G lamblia and other microaero...
Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics
Abstract Mycobacterium tuberculosis M tuberculosis is considered innately resistant to lactam antibiotics However there is evidence that susceptibility to lactam antibiotics in combination with lactamase inhibitors is variable among clinical isolates and these may present therapeutic options for drugresistant cases Here we report o
Cytokines In Cancer Drug Resistance: Cues To New Therapeutic Strategies
Abstract The development of oncoproteintargeted anticancer drugs is an invaluable weapon in the war against cancer However cancers do not give up without a fight They may develop multiple mechanisms of drug resistance including apoptosis inhibition drug expulsion and increased proliferation that reduce the effectiveness of the drug The collective...
An Update On The Role Of Intestinal Cytochrome P450 Enzymes In Drug Disposition
Abstract Oral administration is the most commonly used route for drug treatment Intestinal cytochrome P CYPmediated metabolism can eliminate a large proportion of some orally administered drugs before they reach systemic circulation while leaving the passage of other drugs unimpeded A better understanding of the ability of intestinal P enzymes to...
Loading Of Tacrolimus Containing Lipid Based Drug Delivery Systems Into Mesoporous Silica For Extended Release
Abstract Many studies had been focused on designing tacrolimus sustained release preparations based on solid dispersion technique but no one had tried to employ mesoporous silica as the carrier material to realize this goal The purpose of this study was to develop a novel simple and environmental friendly drug loading method with mesoporous silica...
