Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
New Agents For The Treatment Of Drug-resistant Mycobacterium Tuberculosis
Abstract Inadequate dosing and incomplete treatment regimens coupled with the ability of the tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs have fueled the rise of multidrugresistant tuberculosis MDRTB Treatment of MDRTB infections is a major clinical challenge that has few viable or effective solutions t...
Computational Approaches In Target Identification And Drug Discovery
Abstract In the big data era voluminous datasets are routinely acquired stored and analyzed with the aim to inform biomedical discoveries and validate hypotheses No doubt data volume and diversity have dramatically increased by the advent of new technologies and open data initiatives Big data are used across the whole drug discovery pipeline from...
A Review Of Global Initiatives To Fight Antibiotic Resistance And Recent Antibiotics' Discovery
Abstract Data from across the world have shown an overall decline in the antibiotic pipeline and continually rising resistance to all firstline and lastresort antibiotics The gaps in our knowledge of existing prevalence and mechanisms of antibiotic resistance ABR are all too well known Several decades of antibiotic abuse in humans animals and agri...
Investigation Of Salicylate Hepatic Responses In Comparison With Chemical Analogues Of The Drug
Abstract Antihyperglycaemic effects of the hydroxybenzoic acid salicylate might stem from effects of the drug on mitochondrial uncoupling activation of AMPactivated protein kinase and inhibition of NFB signalling Here we have gauged the contribution of these effects to control of hepatocyte glucose production comparing salicylate with inactive hyd...
Critical parameters in targeted drug development: the pharmacological audit trail
Abstract The Pharmacological Audit Trail PhAT comprises a set of critical questions that need to be asked during discovery and development of an anticancer drug Key aspects include defining a patient population establishing pharmacokinetic characteristics providing evidence of target engagement pathway modulation and biological effect with proo...
Charge-reversal Nanoparticles: Novel Targeted Drug Delivery Carriers
Abstract Spurred by significant progress in materials chemistry and drug delivery chargereversal nanocarriers are being developed to deliver anticancer formulations in spatial temporal and dosagecontrolled approaches Chargereversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface T...
Progress And Perspectives On Targeting Nanoparticles For Brain Drug Delivery
Abstract Due to the ability of the bloodbrain barrier BBB to prevent the entry of drugs into the brain it is a challenge to treat central nervous system disorders pharmacologically The development of nanotechnology provides potential to overcome this problem In this review the barriers to braintargeted drug delivery are reviewed including the BBB
PBPK Modeling And Simulation In Drug Research And Development
Abstract Physiologically based pharmacokinetic PBPK modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data It can also explore the effects of various physiologic parameters such as age ethnicity or disease status on human pharmacokinetics as well as guide dose and dose regiment selecti...
Structure-based Drug Discovery For Prion Disease Using A Novel Binding Simulation
Abstract The accumulation of abnormal prion protein PrPSc converted from the normal cellular isoform of PrP PrPC is assumed to induce pathogenesis in prion diseases Therefore drug discovery studies for these diseases have focused on the protein conversion process We used a structurebased drug discovery algorithm termed Nagasaki University Docking...
Preparation And Application Of Functionalized Nano Drug Carriers
Abstract Objective Targeting at category memory characteristics and preparation methods of functionalized nano drugs preparation technology of functionalized nano drug carriers is studied and then important role of functionalized nano drug carrier in preparation of medicine is studied Methods
