Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
The model beetle Tribolium castaneum can be used as an early warning system for transgenerational epigenetic side effects caused by pharmaceuticals
Abstract Pharmaceuticals are not currently tested for transgenerational and epigenetic side effects The use of vertebrates as preclinical research models is limited by their long generation times low numbers of progeny and ethical concerns In contrast invertebrates such as insects breed rapidly produce many offspring and are more ethically accepta...
What do pharmaceutical industry professionals in Europe believe about involving patients and the public in research and development of medicines? A qualitative interview study
Abstract Objectives To explore Europeanbased pharmaceutical industry professionals beliefs about patient and public involvement PPI in medicines research and development RD Setting Pharmaceutical companies in the UK Poland and Spain
Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study)
Abstract Introduction An increasing number of people are living with multimorbidity The evidence base for how best to manage these patients is weak Current clinical guidelines generally focus on single conditions which may not reflect the needs of patients with multimorbidity The aim of the D study is to
Pharmaceutical treatments to prevent recurrence of endometriosis following surgery: a model-based economic evaluation
Abstract Objective Conduct an economic evaluation based on best currently available evidence comparing alternative treatments levonorgestrelreleasing intrauterine system depotmedroxyprogesterone acetate combined oral contraceptive pill COCP and no treatment to prevent recurrence of endomet
Trends in clinical development timeframes for antiviral drugs launched in the UK, 1981–2014: a retrospective observational study
Abstract Objectives Recent decades have witnessed the development of highly innovative new antiviral drug therapies However there are concerns that rising costs and lengthening development times could have implications for future patient access to innovative new drugs We sought to establish whether the tim
The effect of pharmaceutical care in the elderly patients with type 2 diabetes mellitus
Keywords Pharmaceutical care Type diabetes mellitus Quality of life Clinical outcomes Pharmaceutical care plays a crucial role in reducing mortality and morbidities of the patients A hospital based quasiexperimental study was conducted with elderly patients with type diabetes who attended at the diabetes clinic of No M
The effects of shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV: a systematic review protocol
Abstract Introduction Shifting selected antiretroviral therapy ART tasks from specialised healthcare workers to those with shorter or less formal training has been implemented in resourcelimited settings to alleviate critical shortages of human resources for health However the specifics of shifting ART d
Development and validation of an instrument to assess treatment adherence for each individual drug taken by a patient
Abstract Objective To develop and validate an instrument to assess adherence to each individual drug taken by patients undergoing longterm treatment Design Multicentre prospective observational validation study
Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis
Abstract The evolution and impact of the published literature surrounding the transdisciplinary multifaceted topic of pharmaceuticals as contaminants in the environment is examined for the first time in an historical context The preponderance of literature cited in this examination represents the earlier works As an historical chronology the focus...
Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain
Abstract Phosphodiesterases PDEs are enzymes that play a major role in cell signalling by hydrolysing the secondary messengers cyclic adenosine monophosphate cAMP andor cyclic guanosine monophosphate cGMP throughout the body and brain Altered cyclic nucleotidemediated signalling has been associated with a wide array of disorders including neurodeg...
