Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Trends in clinical development timeframes for antiviral drugs launched in the UK, 1981–2014: a retrospective observational study
Abstract Objectives Recent decades have witnessed the development of highly innovative new antiviral drug therapies However there are concerns that rising costs and lengthening development times could have implications for future patient access to innovative new drugs We sought to establish whether the tim
The effect of pharmaceutical care in the elderly patients with type 2 diabetes mellitus
Keywords Pharmaceutical care Type diabetes mellitus Quality of life Clinical outcomes Pharmaceutical care plays a crucial role in reducing mortality and morbidities of the patients A hospital based quasiexperimental study was conducted with elderly patients with type diabetes who attended at the diabetes clinic of No M
The effects of shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV: a systematic review protocol
Abstract Introduction Shifting selected antiretroviral therapy ART tasks from specialised healthcare workers to those with shorter or less formal training has been implemented in resourcelimited settings to alleviate critical shortages of human resources for health However the specifics of shifting ART d
Development and validation of an instrument to assess treatment adherence for each individual drug taken by a patient
Abstract Objective To develop and validate an instrument to assess adherence to each individual drug taken by patients undergoing longterm treatment Design Multicentre prospective observational validation study
Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis
Abstract The evolution and impact of the published literature surrounding the transdisciplinary multifaceted topic of pharmaceuticals as contaminants in the environment is examined for the first time in an historical context The preponderance of literature cited in this examination represents the earlier works As an historical chronology the focus...
Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain
Abstract Phosphodiesterases PDEs are enzymes that play a major role in cell signalling by hydrolysing the secondary messengers cyclic adenosine monophosphate cAMP andor cyclic guanosine monophosphate cGMP throughout the body and brain Altered cyclic nucleotidemediated signalling has been associated with a wide array of disorders including neurodeg...
Evaluation of dose-efficacy of sorafenib and effect of transarterial chemoembolization in hepatocellular carcinoma patients: a retrospective study
Abstract Background Transarterial chemoembolization TACE and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma HCC patients respectively High costs with adverse events AE of sorafenib might limit sorafenib dosage further affecting therapeutic response To at
Identifying Viable Regulatory and Innovation Pathways for Regenerative Medicine
Abstract The creation of red blood cells for the blood transfusion markets highly represents an innovative approach of regenerative medicine with a medium term year prospect for first clinical study This article describes a research analysis of a project to derive red blood cells from human embryonic stem cells including the systemic challenges a...
Using Residence Time Distributions (RTDs) to Address the Traceability of Raw Materials in Continuous Pharmaceutical Manufacturing
Abstract Continuous processing in pharmaceutical manufacturing is a relatively new approach that has generated significant attention While it has been used for decades in other industries showing significant advantages the pharmaceutical industry has been slow in its adoption of continuous processing primarily due to regulatory uncertainty This pa...
Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection
Abstract In December of chikungunya virus CHIKV an alphavirus in the family Togaviridae was introduced to the island of Saint Martin in the Caribbean resulting in the first autochthonous cases reported in the Americas As of January local and imported CHIKV has been reported in American countries with over million suspected cases CHIKV c
