Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach
Abstract Background Artemisininresistant falciparum malaria has emerged in Southeast Asia posing a major threat to malaria control It is characterised by delayed asexualstage parasite clearance which is the reference comparator for the molecular marker Kelch and in vitro sensitivity tests How
Integrity testing of Planova™ BioEX virus removal filters used in the manufacture of biological products
Abstract Confirmation of virus filter integrity is crucial for ensuring the safety of biological products Two main types of virus filter defects may produce inconsistent and undesirable performance in virus removal improper poresize distribution across the membrane and specific damage such as tears broken fibers or pinholes Two integrity tests are...
Complaints, Complainants, and Rulings Regarding Drug Promotion in the United Kingdom and Sweden 2004–2012: A Quantitative and Qualitative Study of Pharmaceutical Industry Self-Regulation
Abstract Background In many European countries medicines promotion is governed by voluntary codes of practice administered by the pharmaceutical industry under its own system of selfregulation Involvement of industry organizations in policing promotion has been proposed to deter illicit conduct but few detailed studies on selfregulation have been...
Synthetic Biodegradable Polymers Used in Controlled Drug Delivery System: An Overview
Abstract Polymers are becoming increasingly important in the field of drug delivery The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids suspensions and emulsions Use of polymer is now extended to controlled release and targeting drug delivery system Polymers are...
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
Objective Research identified promising therapeutics in cell models of Amyotrophic Lateral Sclerosis ALS but there is limited progress translating effective treatments to animal models and patients and ALS remains a disease with no effective treatment One explanation stems from an acquired pharmacoresistance driven by the drug efflux transporters...
A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form
Abstract A rapid simple sensitive and accurate isocratic reversedphase stabilityindicating high performance liquid chromatography method has been developed and validated for the determination of stiripentol and its degradation product in its bulk form and pharmaceutical dosage form Chromatographic separation was achieved on a Symmetry C column and...
Dynamic Conformational Change Regulates the Protein-DNA Recognition: An Investigation on Binding of a Y-Family Polymerase to Its Target DNA
Abstract ProteinDNA recognition is a central biological process that governs the life of cells A protein will often undergo a conformational transition to form the functional complex with its target DNA The protein conformational dynamics are expected to contribute to the stability and specificity of DNA recognition and therefore may control the f...
A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion
Insulin is a major regulator of metabolism in metazoans including the fruit fly Drosophila melanogaster Genomewide association studies GWAS suggest a genetic basis for reductions of both insulin sensitivity and insulin secretion
Correction: Changes in Drug Utilization during a Gap in Insurance Coverage: An Examination of the Medicare Part D Coverage Gap
Abstract Since the manuscripts publication the authors have been working on other unrelated studies using the same database The authors found results in these new unrelated studies to be implausible and so undertook an intensive several weekslong investigation to determine whether the common database was in some way incorrectly assembled or was mi
Genetic Dynamic Analysis of the Influenza A H5N1 NS1 Gene in China
Abstract The direct precursors of the AGooseGuangdong GSGD virus lineage and its reassortants have been established geographically and ecologically To investigate the variation and evolutionary dynamics of HN viruses wholegenome viral sequences n were retrieved from the NCBI Influenza Virus Resource Here we present phylogenetic evide
