Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
The effects of shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV: a systematic review protocol
Abstract Introduction Shifting selected antiretroviral therapy ART tasks from specialised healthcare workers to those with shorter or less formal training has been implemented in resourcelimited settings to alleviate critical shortages of human resources for health However the specifics of shifting ART d
Development and validation of an instrument to assess treatment adherence for each individual drug taken by a patient
Abstract Objective To develop and validate an instrument to assess adherence to each individual drug taken by patients undergoing longterm treatment Design Multicentre prospective observational validation study
Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis
Abstract The evolution and impact of the published literature surrounding the transdisciplinary multifaceted topic of pharmaceuticals as contaminants in the environment is examined for the first time in an historical context The preponderance of literature cited in this examination represents the earlier works As an historical chronology the focus...
Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain
Abstract Phosphodiesterases PDEs are enzymes that play a major role in cell signalling by hydrolysing the secondary messengers cyclic adenosine monophosphate cAMP andor cyclic guanosine monophosphate cGMP throughout the body and brain Altered cyclic nucleotidemediated signalling has been associated with a wide array of disorders including neurodeg...
Evaluation of dose-efficacy of sorafenib and effect of transarterial chemoembolization in hepatocellular carcinoma patients: a retrospective study
Abstract Background Transarterial chemoembolization TACE and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma HCC patients respectively High costs with adverse events AE of sorafenib might limit sorafenib dosage further affecting therapeutic response To at
Identifying Viable Regulatory and Innovation Pathways for Regenerative Medicine
Abstract The creation of red blood cells for the blood transfusion markets highly represents an innovative approach of regenerative medicine with a medium term year prospect for first clinical study This article describes a research analysis of a project to derive red blood cells from human embryonic stem cells including the systemic challenges a...
Using Residence Time Distributions (RTDs) to Address the Traceability of Raw Materials in Continuous Pharmaceutical Manufacturing
Abstract Continuous processing in pharmaceutical manufacturing is a relatively new approach that has generated significant attention While it has been used for decades in other industries showing significant advantages the pharmaceutical industry has been slow in its adoption of continuous processing primarily due to regulatory uncertainty This pa...
Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection
Abstract In December of chikungunya virus CHIKV an alphavirus in the family Togaviridae was introduced to the island of Saint Martin in the Caribbean resulting in the first autochthonous cases reported in the Americas As of January local and imported CHIKV has been reported in American countries with over million suspected cases CHIKV c
FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events
Abstract Chromosomal translocation CT is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia A tumorspecific fusion gene event may occur when a translocation joins two separate genes Currently various CT databases provide information about fusion genes and their genomic elements However no...
Analytical and statistical comparability of generic enoxaparins from the US market with the originator product
Abstract Lowmolecularweight heparins LMWHs are complex anticoagulant drugs made from heparin porcine mucosa starting material Enoxaparin sodium manufactured by Sanofi is one of the most widely prescribed LMWHs and has been used since in the USA In US Food and Drug Administration approval for supplying generic enoxaparin was granted to Sandoz and...
