Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Analytical Quality by Design: A Tool for Regulatory Flexibility and Robust Analytics
Abstract Very recently Food and Drug Administration FDA has approved a few new drug applications NDA with regulatory flexibility for quality by design QbD based analytical approach The concept of QbD applied to analytical method development is known now as AQbD analytical quality by design It allows the analytical method for movement within method...
An Empirical Analysis of Primary and Secondary Pharmaceutical Patents in Chile
Abstract We analyze the patent filing strategies of foreign pharmaceutical companies in Chile distinguishing between primary active ingredient and secondary patents patents on modified compounds formulations dosages particular medical uses etc There is prior evidence that secondary patents are used by pharmaceutical originator c
Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach
Abstract Background Artemisininresistant falciparum malaria has emerged in Southeast Asia posing a major threat to malaria control It is characterised by delayed asexualstage parasite clearance which is the reference comparator for the molecular marker Kelch and in vitro sensitivity tests How
Integrity testing of Planova™ BioEX virus removal filters used in the manufacture of biological products
Abstract Confirmation of virus filter integrity is crucial for ensuring the safety of biological products Two main types of virus filter defects may produce inconsistent and undesirable performance in virus removal improper poresize distribution across the membrane and specific damage such as tears broken fibers or pinholes Two integrity tests are...
Complaints, Complainants, and Rulings Regarding Drug Promotion in the United Kingdom and Sweden 2004–2012: A Quantitative and Qualitative Study of Pharmaceutical Industry Self-Regulation
Abstract Background In many European countries medicines promotion is governed by voluntary codes of practice administered by the pharmaceutical industry under its own system of selfregulation Involvement of industry organizations in policing promotion has been proposed to deter illicit conduct but few detailed studies on selfregulation have been...
Synthetic Biodegradable Polymers Used in Controlled Drug Delivery System: An Overview
Abstract Polymers are becoming increasingly important in the field of drug delivery The pharmaceutical applications of polymers range from their use as binders in tablets to viscosity and flow controlling agents in liquids suspensions and emulsions Use of polymer is now extended to controlled release and targeting drug delivery system Polymers are...
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
Objective Research identified promising therapeutics in cell models of Amyotrophic Lateral Sclerosis ALS but there is limited progress translating effective treatments to animal models and patients and ALS remains a disease with no effective treatment One explanation stems from an acquired pharmacoresistance driven by the drug efflux transporters...
A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form
Abstract A rapid simple sensitive and accurate isocratic reversedphase stabilityindicating high performance liquid chromatography method has been developed and validated for the determination of stiripentol and its degradation product in its bulk form and pharmaceutical dosage form Chromatographic separation was achieved on a Symmetry C column and...
Dynamic Conformational Change Regulates the Protein-DNA Recognition: An Investigation on Binding of a Y-Family Polymerase to Its Target DNA
Abstract ProteinDNA recognition is a central biological process that governs the life of cells A protein will often undergo a conformational transition to form the functional complex with its target DNA The protein conformational dynamics are expected to contribute to the stability and specificity of DNA recognition and therefore may control the f...
A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion
Insulin is a major regulator of metabolism in metazoans including the fruit fly Drosophila melanogaster Genomewide association studies GWAS suggest a genetic basis for reductions of both insulin sensitivity and insulin secretion
