Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
Objective Research identified promising therapeutics in cell models of Amyotrophic Lateral Sclerosis ALS but there is limited progress translating effective treatments to animal models and patients and ALS remains a disease with no effective treatment One explanation stems from an acquired pharmacoresistance driven by the drug efflux transporters...
A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form
Abstract A rapid simple sensitive and accurate isocratic reversedphase stabilityindicating high performance liquid chromatography method has been developed and validated for the determination of stiripentol and its degradation product in its bulk form and pharmaceutical dosage form Chromatographic separation was achieved on a Symmetry C column and...
Dynamic Conformational Change Regulates the Protein-DNA Recognition: An Investigation on Binding of a Y-Family Polymerase to Its Target DNA
Abstract ProteinDNA recognition is a central biological process that governs the life of cells A protein will often undergo a conformational transition to form the functional complex with its target DNA The protein conformational dynamics are expected to contribute to the stability and specificity of DNA recognition and therefore may control the f...
A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion
Insulin is a major regulator of metabolism in metazoans including the fruit fly Drosophila melanogaster Genomewide association studies GWAS suggest a genetic basis for reductions of both insulin sensitivity and insulin secretion
Correction: Changes in Drug Utilization during a Gap in Insurance Coverage: An Examination of the Medicare Part D Coverage Gap
Abstract Since the manuscripts publication the authors have been working on other unrelated studies using the same database The authors found results in these new unrelated studies to be implausible and so undertook an intensive several weekslong investigation to determine whether the common database was in some way incorrectly assembled or was mi
Genetic Dynamic Analysis of the Influenza A H5N1 NS1 Gene in China
Abstract The direct precursors of the AGooseGuangdong GSGD virus lineage and its reassortants have been established geographically and ecologically To investigate the variation and evolutionary dynamics of HN viruses wholegenome viral sequences n were retrieved from the NCBI Influenza Virus Resource Here we present phylogenetic evide
Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis
Abstract Rationale Tuberculosis remains a worldwide problem particularly with the advent of multidrug resistance Shortening therapy duration for Mycobacterium tuberculosis is a major goal requiring generation of optimal kill rate and resistancesuppression Combination therapy is required to attain the goal of shorter therapy Objectives Our objec...
Methods for Specifying the Target Difference in a Randomised Controlled Trial: The Difference ELicitation in TriAls (DELTA) Systematic Review
Abstract Background Randomised controlled trials RCTs are widely accepted as the preferred study design for evaluating healthcare interventions When the sample size is determined a target difference is typically specified that the RCT is designed to detect This provides reassurance that the study w
Recent Mitochondrial DNA Mutations Increase the Risk of Developing Common Late-Onset Human Diseases
Abstract Mitochondrial DNA mtDNA is highly polymorphic at the population level and specific mtDNA variants affect mitochondrial function With emerging evidence that mitochondrial mechanisms are central to common human diseases it is plausible that mtDNA variants contribute to the missing heritability of several complex traits Given the cent
Adverse Effects and Regimen Switch among Patients on Antiretroviral Treatment in a Resource Limited Setting in Ethiopia
Abstract Background Highly active antiretroviral therapy is the cornerstone of management of patients with human immunodeficiency virus infection Antiretroviral therapy can prolong survival of patients however this drugs are associated with adverse effects that can affect patient adherence and if severe may require regimen change The aim of the stu...
