Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis
Standard treatment for active tuberculosis TB requires drug treatment with at least four drugs over six months Shorterduration therapy would mean less need for strict adherence and reduced risk of bacterial resistance
Mathematical modelling reveals cellular dynamics within tumour spheroids
Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and response to treatment of different cancer cell lines Their popularity is largely due to the reproducible manner in which spheroids grow
Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Posttraumatic osteoarthritis PTOA is associated with cartilage degradation ultimately leading to disability and decrease of quality of life Two key mechanisms have been suggested to occur in PTOA tissue inflammation
Stochastic ordering of complexoform protein assembly by genetic circuits
Topdown proteomics has enabled the elucidation of heterogeneous protein complexes with different cofactors posttranslational modifications and protein membership This heterogeneity is believed to play a previously unknown role in cellular processes
Statistical analysis of 3D localisation microscopy images for quantification of membrane protein distributions in a platelet clot model
We present the software platform CALM that allows for a comparative analysis of D localisation microscopy data representing protein distributions in two biological samples The indepth statistical analysis reveals differences between samples at the nanoscopic level
Early transmission of sensitive strain slows down emergence of drug resistance in Plasmodium vivax
The spread of drug resistance of Plasmodium falciparum and Plasmodium vivax parasites is a challenge towards malaria elimination P falciparum has shown an early and severe drug resistance in comparison to P vivax in various countries
A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks
Metabolism underpins the pathogenic strategy of the causative agent of TB Mycobacterium tuberculosis Mtb and therefore metabolic pathways have recently reemerged as attractive drug targets A powerful approach to study Mtb metabolism as a whole
Benchmarking Predictions of MHC Class I Restricted T Cell Epitopes in a Comprehensively Studied Model System
T cell epitope candidates are commonly identified using computational prediction tools in order to enable applications such as vaccine design cancer neoantigen identification development of diagnostics and removal of unwanted immune responses against protein therapeutics
In Silico Analysis of Hypoxia Activated Prodrugs in Combination with Anti Angiogenic Therapy through Nanocell Delivery
Tumour hypoxia is a wellstudied phenomenon with implications in cancer progression treatment resistance and patient survival While a clear adverse prognosticator hypoxia is also a theoretically ideal target for guided drug delivery
Balance between Asymmetry and Abundance in Multi-Domain DNA-Binding Proteins may Regulate the Kinetics of their Binding to DNA
DNA sequences are often recognized by multidomain proteins that may have higher affinity and specificity than singledomain proteins However the higher affinity to DNA might be coupled with slower recognition kinetics In this study we address this balance between stability and kinetics for multidomain CysHis CH type zincfinger ZF proteins
