Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARSCoV evolution and host immunity is critical to control COVID pandemics At the core is an armsrace between SARSCoV antibody and angiotensinconverting enzyme ACE recognition a function of the viral protein spike Mutations in spike impacting
Probing T-cell response by sequence-based probabilistic modeling
With the increasing ability to use highthroughput nextgeneration sequencing to quantify the diversity of the human T cell receptor TCR repertoire the ability to use TCR sequences to infer antigenspecificity could greatly aid potential diagnostics and therapeutics
Novel EDGE encoding method enhances ability to identify genetic interactions
Assumptions are made about the genetic model of single nucleotide polymorphisms SNPs when choosing a traditional genetic encoding additive dominant and recessive Furthermore SNPs across the genome are unlikely to demonstrate identical genetic models However running SNPSNP interaction analyses with every combination
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells
Mammalian cells release different types of vesicles collectively termed extracellular vesicles EVs EVs contain cellular microRNAs miRNAs with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stability of individual mRNAs and the cells transcriptome
Machine learning and deep learning techniques to support clinical diagnosis of arboviral diseases: A systematic review
Neglected tropical diseases NTDs primarily affect the poorest populations often living in remote rural areas urban slums or conflict zones Arboviruses are a significant NTD category spread by mosquitoes Dengue Chikungunya and Zika are three arboviruses that affect a large proportion of the population in Latin and South America
High-throughput framework for genetic analyses of adverse drug reactions using electronic health records
Understanding the contribution of genetic variation to drug response can improve the delivery of precision medicine However genomewide association studies GWAS for drug response are uncommon and are often hindered by small sample sizes
Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells
COVID vaccines based on the Spike protein of SARSCoV have been developed that appear to be largely successful in stopping infection However therapeutics that can help manage the disease are still required until immunity has been achieved globally
Bioinformatic analysis identifies potential key genes of epilepsy
Epilepsy is one of the most common brain disorders worldwide It is usually hard to be identified properly and a third of patients are drugresistant Genes related to the progression and prognosis of epilepsy are particularly needed to be identified
Virus-derived variation in diverse human genomes
Acquisition of genetic material from viruses by their hosts can generate interhost structural genome variation We developed computational tools enabling us to study virusderived structural variants SVs in populationscale whole genome sequencing WGS datasets and applied them to humans Although SVs had already been cataloged in these subjects
The landscape of antibody binding in SARS-CoV-2 infection
The search for potential antibodybased diagnostics vaccines and therapeutics for pandemic severe acute respiratory syndrome coronavirus SARSCoV has focused almost exclusively on the spike S and nucleocapsid N proteins Coronavirus membrane M ORFa and ORF proteins are humoral immunogens in other coronaviruses
