Senior Lecturer, School of Pharmacy
Ishwar Singh is a Senior Lecturer in Biological Chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as the Alexander von Humboldt fellowship, Germany; and Sen..
Patients in the st century have joined an increasingly visible group of empowered consumers These consumers are techsavvy informed handson global and increasingly in control of when where and how they are treated Personalized medicine is the exciting result of these empowered patients seeking higher standards of care and the rapid adoption of new techniques in genomic and proteomic science Define..
Abstract Mixedmode chromatography MMC is a fast growing area in recent years thanks to the new generation of mixedmode stationary phases and better understanding of multimode interactions MMC has superior applications in the separation of compounds that are not retained or not well resolved by typical reversedphase LC methods especially for polar and charged molecules Due to the multiple retention modes that a single MMC column can offer often M..
Abstract Hydrazine NH is a known genotoxic impurity that typically needs to be controlled down to low ppm level in pharmaceutical development Hydrazine however is a challenging molecule to analyze using conventional analytical techniques due to its physical and chemical properties eg lack of chromophore absence of any..
Genetic engineers and researchers alike have explicitly shared their affinity towards the geneediting tool called CRISPRCas This device alters targeted genes effortlessly thereby p..
The demand on drug manufacturers to get operations right has never been more urgent. Most agree the..
These countries contributed billion to the global pharmaceuticals industry in with a compound annual growth rate CAGR of between and The top emerging countries are expected to reach a ..
The bioprinting of tissues and organs has been big news recently However the patenting of bioprinting techniques has quietly been going on for years This article will discuss the patents covering the three process phases of bioprinting the exceptions to patent infringement for experimental uses and the prospects for further patenting and patent infringement lawsuits..
The quest to undertake biological targets that are based on the regulation of signalling pathways is challenging the classical thinking in the drug discovery arena Historically the complexity of the biological system was underestimated It is now wellaccepted that compared to old biological targets that were focused on single gene or gene products we need to undertake targets that are derived from complex and dynamic signaling pathways..
Issues like approval delays deficiencies of functioning of CROs and other stake holders liabilities and compensation to injured subjects insurance issues etc still remain in India which has made multinational companies to rethink on opting for India to conduct clinical trials in India recently There is a need for a law to ensure that the people who undergo clinical trials are not exploited and should be well informed about risk as well to provide..
This article is a firsthand account of the experiences of Pharmadule in guiding leading Chinese manufacturers through facility investment projects aimed at compliance with Chinese US and EU GMP requirements These manufacturers have been among the first in the world to fully embrace the work procedures outlined in ICH Q Q and Q Implementing these guidelines in large organisations would be a challenge with any global market but it turns out that the Chinese market offers both advantages and cultur..
The article presents a novel approach to applying Quality by Design QbD principles to the development of analytical methods Common critical parameters in HPLC gradient time temperature pH of the aqueous eluent and stationary phase are evaluated within the Quality by Design framework It is useful for the robust analytical method development and Design Space optimisation..