KNOWLEDGE BANK

Interviews

Knowledge Gain Through High Parallel Bioprocess Setups

Product Life Cycle Manager, Eppendorf AG
Sebastian Kleebank studied Bioengineering at the University of Applied Sciences in Juelich followed by his PhD at the RWTH Aachen Institute for Molecular Biotechnology In his actual position as a Product Life Cycle Manager at Eppendorf AG Business Unit Bioprocess he is responsible for the smallscale product portfolio During his years in the bioprocess industry he gained a lot of experience in sma...

Articles

Approach for Producing Pharmaceuticals in Layer By Layer Fashion: Additive Manufacturing

D printing DP is a computeraided design with unique technology of prototyping layerbylayer fabricating D objects in the form of digital designs to achieve unmatched suppleness time conservation and extraordinary manufacturing capability of pharmaceutical dosage forms It works by depositing binding and polymerisation through layering until the desired object

Research Insights

Roadmap for the use of Base Editors to Decipher Drug Mechanism of Action

CRISPR base editors are powerful tools for largescale mutagenesis studies This kind of approach can elucidate the mechanism of action of compounds a key process in drug discovery Here we explore the utility of base editors in an early drug discovery context focusing on Gprotein

Case Studies

Quality Management In Clinical Trials: An Observational Case Study By Pfizer

Abstract Clinical trials are conducted to collect the data necessary to provide information for academia industry and regulators to make decisions about the safety and efficacy of the disease illness or preventative medicines under study To ensure investigators are following the protocol complying with regulatory and G

Techno Trends

Singapore Government Unveils New Biopharmaceutical Manufacturing Facilities to Boost Production Capacity

Singapore enhances its biopharmaceutical manufacturing capabilities with new facilities to meet growing global demand

White Papers

Cloud Computing in the Laboratory Informatics Solutions and Validation Approaches

In the modern business environment, a significant portion of work is conducted using computerized systems. Many solutions are used to complete tasks, including simple desktop programs like email and Microsoft Office to enterprise-wide, global systems like ERP (Enterprise Resource Planning), MES (Manufacturing Execution System), and LIMS

TOP ARTICLES

1

Effect of Size of Protein Therapeutics on Brain Pharmacokinetics following Systemic Administration

Hsueh-Yuan Chang

Chang supports the preclinical-to-clinical PKPD translation and human efficacious dose prediction of new biological entities at Boehringer Ingelheim. Dr. Chang obtained his MS and Ph.D. in Pharmaceutical Sciences at the University at Buffalo. Under Dr. Dhaval Shah’s mentorship, Dr. Chang investigated antibody and protein therapeutic disposition in the rat brain using large-poremicrodialysis and developed a translational brain PBPK model for monoclonal antibodies.

 

Dhaval K Shah

Dhaval K Shah is an Associate Professor of Pharmaceutical Sciences at the State University of New York at Buffalo. Prior to becoming the faculty Prof. Shah served as a Principle Scientist in the ‘Translational Research-Modeling & Simulation’ group at Pfizer Inc. His research focuses on understanding the determinants for the absorption, distribution, metabolism, and elimination (ADME) of protein therapeutics. His lab uses the principles of Pharmacokinetics-Pharmacodynamics (PK-PD) Modeling & Simulation to support the discovery, clinical translation, and late phase development of novel biologics like engineered antibodies, multi-specific proteins, immuno-oncology agents, engineered T cells, and antibody-drug conjugates.

 

Shengjia Wu

Shengjia Wu is a PhD student in the pharmaceutical sciences at the State University of New York at Buffalo. His research focuses on understanding and modeling the macromolecule distribution in the central nervous system.

 

Yingyi Li

Yingyi Li gained her master’s degree of pharmaceutical sciences in University at Buffalo. When Yingyi was a master student, she was working in Dr. Dhaval Shah’s lab and became more experienced in PBPK modeling. Yingyi is currently a scientist in the field of pharmacometrics and translational PK-PD in Enhanced Pharmacodynamics.

 

2

Futuristic Application of Human-On-A-Chip Technology

Joseph Xavier

Joseph Xavier is currently pursuing his PhD in the Division of Toxicology,SCTIMST, Trivandrum, Kerala. He is currently working on the development of multi-organ-on-a-chip for disease modelling and toxicity assessments. His work also focuses on elucidating the cellular mechanism of toxicity of nanomaterials.

 

Akhil Venugopal

Akhil Venugopal is currently working as a Junior Research Fellow in the Division of Toxicology, SCTIMST, Trivandrum. He obtained his Integrated BS-MS in Chemistry from Indian Institute of Science Education and Research (IISER), Mohali. His research work is focused on the fabrication of multi-organ micro physiological devices for pre-clinical studies.

 

Arathi Ashok

Arathi Ashok obtained her Masters in Microbiology from Amrita Vishwa Vidyapeetham, Kerala. She is currently working as a Junior Research Fellow in the Division of Toxicology, SCTIMST, Trivandrum. Her research work lies in the development of organ-on-a chip devices for toxicity assessment.

 

PV. Mohanan

PV. Mohanan, FNASc, FRSB, Scientist-G and Head of Division of Toxicology and Associate Dean (PhD program) in Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India. He has more than 33 years of research experience in Toxicology. He is a Certified Biological Safety Specialist and has authored 233 publications and edited 6 books. He is also a Visiting Professor and Visiting Researcher at Toyo University, Japan.

 

3

Labelling and imaging of Radiopharmaceuticals

Sumel Ashique

Sumel Ashique has been working as an assistant professor in Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India. He has 3.5 years of teaching experience. He has achieved 50+ publications of International and national accredited reputed journals (Scopus, UGC). He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He has also 4 granted patents from IP and Australia, 8 published book chapters in International Books and 12 book chapters have been submitted to well-known publishers like Springer, Elsevier, Bentham and Taylor & Francis. Currently he is editing 5 books under CRC; AAP, Springer and Wiley publisher

 

Radheshyam Pal

Radheshyam Pal is an Assistant Professor at Pandaveswar School of Pharmacy. His areas of expertise in Neuropharmacology. He specifically works on the role of natural products in the CNS. He has 2 years of teaching experience. He has 2 patents and also 10 book chapters submitted in international publisher.

 

4

Application of Artificial Intelligence in Development Safety Update Report Preparation

Maria Carolina Braga

Maria Carolina Braga holds a degree in Pharmaceutical Sciences with a specialization in Clinical Pharmacy. She has over 10 years of experience in pharmacovigilance and recently completed a master’s degree in Pharmacovigilance and Pharmacoepidemiology, focusing her research on the use of artificial intelligence in aggregate safety report writing.

5

Synbiotics in Metabolic Health

Dr. Neeraj Mishra

Dr. Neeraj Mishra is working as Professor and Head, Department of Pharmaceutics,  in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience.  He has more than 100 publications of International and National repute in recent concepts of novel drug delivery systems, localised drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, colon cancer, and neurodegenerative disorders. Dr. Mishra more than 3700 citations with h- index 32. The total cumulative Impact Factor of his published papers is more than 300 (as per SCOPUS). He has also written 15 Books and 30 book chapters in Elsevier, Bentham, Springer and Wiley Publication etc. He has also been granted 3 international patents and 2 Indian patents.  Dr. Mishra is recipient of “Distinguished Professor Award” 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019.  Dr. Mishra has received the “Distinguished Professor Award '' 2021 from Indian Pharmaceutical Association, MP State Branch, Indore.  Dr Mishra has received Best Academician Award in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India.

Devyani Rajput

Dr. Devyani Rajput is working as an Assistant Professor, Department of Pharmacognosy, in Amity Institute of Pharmacy, Gwalior since Jan 2024. She has around seven years of research experience. Her expertise includes nanotechnology, phytomedicine, and advanced drug delivery systems, with notable contributions to cancer research. She has participated in various national and international conferences, published impactful research, and received prestigious awards, including the BEST SCHOLAR AWARD 2023. She has more than 150 citations with h- index 3. She has received the CSIR travel Grant in April 2024 for presenting her research work in Istanbul University.

press releasesRead more...

Merck Opens €300 Million Asia-Pacific Bioprocessing Center in Daejeon, South Korea

Merck a leading science and technology company today opened its new AsiaPacific Bioprocessing Production Center in Daejeon South Korea The center represents an investment of more than million the companys largest Life Science investment in AsiaPacific to date

Flagship Pioneering Forms Etcelera to Move Drug Discovery from Probability to Prediction

Flagship Pioneering a scientific innovation engine for transformative platforms and products today announced the formation of Etcelera a company created by the merger of the platforms of Cellarity Cellarity Platform Inc Etiome and Empress Therapeutics to pioneer causal intelligence in human biology...

Junshi Biosciences Announces Acceptance of the Supplemental New Drug Application of Toripalimab (Subsutaneous Injection) for the 1st-Line Treatment of HER2-Expressing Urothelial Carcinoma

Shanghai Junshi Biosciences Co Ltd a leading innovationdriven biopharmaceutical company dedicated to the discovery development and commercialization of novel therapies announced that the supplemental new drug application for the companys product toripalimab injection subcutaneous injection

HUTCHMED Announces Sovleplenib Granted US FDA Orphan Drug Designation for Primary Immune Thrombocytopenia

HUTCHMED China Limited today announces that the US Food and Drug Administration FDA has granted Orphan Drug Designation to sovleplenib for the treatment of primary immune thrombocytopenia ITP an autoimmune disorder that can lead to increased

Transpharmation Ltd. Announces Strategic Acquisition of OrganoTherapeutics SARL

Were delighted to announce the strategic acquisition of OrganoTherapeutics SARL a leader in patientderived organoid technologies that advance the discovery and development of novel therapies for neurodegenerativeCNS disorders

EVERSANA Expands Global Commercialization and AI-Powered HEOR Capabilities with Acquisition of U.K.-based Estima Scientific

EVERSANA a global provider of modern AIpowered commercial services for the biopharmaceutical industry today announced the acquisition of Estima Scientific an innovative Londonbased health economics and outcomes research HEOR technology and services company

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Pharma Forum EMEA 2026

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Cancer R&D 2026

Houston, TX, USA

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10th Dermatology Drug Development

Boston, Massachusetts at The C...

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PDA Aseptic Processing of Biopharma Conference

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Advanced Therapies USA

Hynes Convention Center, Bosto...

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PDA Contamination Control Strategy Workshop

Sheraton Grand Incheon Hotel,...

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11th Microbiome Movement USA Summit

The Colonnade Hotel, Boston, M...

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Nov 2026

Extractables & Leachables Europe

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LATEST NEWSRead more...

Edison Scientific Enters into Agreement with Pfizer to Advance Drug Research and Development

Edison Scientific has entered into an agreement with Pfizer to introduce its Edison AI Platform and AI scientist Kosmos across Pfizers biopharmaceutical research and development activities The collaboration will combine Edison Scientifics artificial intelligence AI technology with Pfizers scientific...

Appian and PSI CRO Partner to Advance AI-driven Clinical Trial Operations

Appian and PSI CRO have entered into a strategic partnership to introduce an artificial intelligence AIpowered solution for clinical trial site identification and selection The solution is now live and is designed to automate site selection across different therapeutic areas medical conditions and...

Adalvo Acquires Romiplostim Biosimilar from Enzene

Adalvo has acquired a romiplostim biosimilar programme from Enzene expanding its portfolio of biosimilars and strengthening its presence in complex biological medicines The programme references Nplate romiplostim a medicine used to treat immune thrombocytopenia ITP in adults and children with chroni...

Twist Bioscience Launches Express Screening Antibodies for Faster Characterisation

Twist Bioscience has expanded its antibody production and characterisation portfolio with the launch of Twist Express Screening Antibodies a service designed to help researchers evaluate large numbers of antibody candidates more quickly The service uses a highthroughput cellfree production process t...

Astellas Enters into Agreement with Audax for Immuno-Oncology Candidate DAX-044

Astellas Pharma and Audax Biosciences have entered into an exclusive option and licence agreement for DAX an investigational antibodycytokine fusion being developed for cancer immunotherapy DAX is designed to deliver interleukin IL an immuneactivating protein more selectively to the tumour microenvi...

Sumitomo Pharma’s Enzomenib Receives Breakthrough Therapy Designation for Relapsed or Refractory KMT2A-Rearranged Acute Leukaemia

Sumitomo Pharma America has announced that the US Food and Drug Administration FDA has granted Breakthrough Therapy designation to enzomenib DSP for treating patients with relapsed or refractory acute leukaemia carrying a KMTA gene rearrangement